Tick Borne Diseases

[skip11]

Thanks a lot for this Evo! Great article. Appreciate the studies links too.

[evolutionkennels]

Thanks a lot for this Evo! Great article. Appreciate the studies links too.

. For dogs that are reasonably stable (for example Bartonella polyarthritis) try starting oneantibiotic (for example doxycycline at 5 mg/kg every 12 hours) and then add the secondantibiotic 5-7 days later. The reason to not start both antibiotics simultaneously is associated witha Jarisch Herxheimer-like reaction, which is a common occurrence in cats and dogs during theinitial treatment for this infection. The reaction (lethargy, fever, potentially vomiting) tends tooccur 4-7 days after starting antibiotics (but is even more delayed in some animals) and is aresult of bacterial injury/death and cytokine release, presumably after achieving high intracellularantibiotic concentrations. Because the patient’s condition can be worse than before startingantibiotics, the clinician often suspects an adverse drug reaction and either stops or switchesantibiotics. This reaction (lethargy, fever, vomiting) generally lasts only a couple of days. Givinganti-inflammatory steroids for a few days may help dogs through this period. Unless clinicaldeterioration continues to progress, it is best to continue the antibiotics that were initially started.The fact that the antibiotics induced a reaction is most likely a reflection of adequate intracellularand intravascular drug concentrations resulting in bacterial death.

very interesting

[evolutionkennels]

A Jarisch–Herxheimer reaction (English: /ˌjɑːrɪʃ ˈhɛərkshaɪmər/) is a reaction to endotoxin-like products released by the death of harmful microorganisms within the body during antibiotic treatment. Efficacious antimicrobial therapy results in lysis (destruction) of bacterial cell membranes, and in the consequent release into the bloodstream of bacterial toxins, resulting in a systemic inflammatory response.
Jarisch–Herxheimer reactions are usually not life-threatening.

The Jarisch–Herxheimer reaction is classically associated with penicillin treatment of syphilis. Duration in syphilis is normally only a few hours. The reaction is also seen in other diseases caused by spirochetes, such as borreliosis (Lyme disease and tick-borne relapsing fever) and leptospirosis, and in Q fever.[1] Similar reactions have also been reported to occur in bartonellosis (including cat scratch disease),[2][3] brucellosis,[4] typhoid fever,[5] trichinosis,[6] and cerebral trypanosomiasis.[7]

[evolutionkennels]

Also , look up Q fever. https://en.wikipedia.org/wiki/Q_fever