Prostaglandins are a group of hormones that have an effect on the uterus by making it contract. The contraction of the uterus pushes the infection out over a period of about a week. The dog will also have to be on antibiotics to prevent any secondary infections.

If memory serves me correctly, the dog gets one or two shots a day for 7 days. Don't quote me on that as it has been years since we've experienced one of those. The only place I've ever been able to get it from is a vet. Some vets will refuse to use the treatment for whatever reason. We turned away from 2 vets who refused the treatment as they insisted our female be spayed. We finally found one willing to do what WE wanted, and both of our females survived. One of them whelped a litter successfully. The other female had another pyometra that didn't respond to the prostaglandin treatment the second time around, so she had to be spayed in order to save her life.