First thing you want to know is if it's an open or closed pyometra.

Treatments can run from antibiotic therapy to using prostaglandins along with antibiotic therapy.

If it's a closed pyometra, I personally don't know what, if anything, can be done for the female aside from having her spayed. Since it's closed, there is no way for the pus and infection to drain, so it just accumulates within the female. Open is definitely the one you want if you have a female with pyometra.

We've never used just Abx therapy, so I can't speak to how effective that works. I believe Jack has done with that success. We've used prostaglandins on the two females we've had that came down with pyometras, and both of them came out fine.