It's funny how many things we look back on in life, and wish we could revisit them with a more mature perspective
Thank you very much for the interesting topic. I will follow-up on this more as I have more time to do so. Cheers!
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Though I get the gist of this quote, all it does is muddy the issue. The issue is whether the substance is safe to use at the recommended dose or not. Whether "all" substances can become toxic, if you overdose the hell out of them, just muddies the issue.
For example, the wormer pyrantel is considered "safe" to use, precisely because even at 20x the dose needed to kill the roundworm there are few known side-effects. Just because you could ultimately give a toxic dose, if you gave a dog enough, doesn't change the fact that pyrantel is considered a non-toxic substance at the recommended dose to do what it is supposed to do. By contrast, piperazine (another wormer) can induce major toxic symptoms at only 2-3x the recommended dose. Therefore, the margin of safety is much less in piperazine.
So the point is this: if the required dose of a substance to "work" at its intended purpose also runs the risk of toxic effects, then that substance cannot be considered a "safe" drug to take, but in fact is a risky drug/substance to take. By contrast, if another drug can be given at a specific dose to achieve the same effect, and runs zero risk of toxic effects, then that drug is considered safe to use.
I am not sure this inflammatory statement about the FDA is necessarily true. The FDA may be a slow-turning mechanism, but it admits the efficacy of a number of drugs that actually do work and actually are safe. Clearly there must be some merit to whether Ge132 works, otherwise they wouldn't be spending so much money running a 7-year test on it. The very fact that they're running such a test means that the substance has shown promise. But there may also be some unwanted effects to the substance, and I think by doing a 7-year test they're doing what they're supposed to be doing, rather than playing guessing-games or "repeating what they hear."
I am not sure if you even read all of these studies here, but even they describe possible renal failure:
"Germanium is not an essential element. Its acute toxicity is low. However, at least 31 reported human cases linked prolonged intake of germanium products with renal failure and even death. Signs of kidney dysfunction, kidney tubular degeneration, and germanium accumulation were observed. Other adverse effects were anemia, muscle weakness, and peripheral neuropathy. Recovery of renal function is slow and incomplete even long after germanium intake was stopped. The total dose of ingested germanium (as dioxide, carboxyethyl germanium sesquioxide, germanium-lactate-citrate, or unspecified forms) varied from 15 to over 300 g; the exposure duration varied from 2 to 36 months."
Reference
Therefore, it seems the FDA isn't lying. What it seems like is that they're trying to be thorough.
Well, there is a major difference between a LETHAL dose and a dose that can create negative side-effects. So you're arguing something else now. I am sure it would take quite a lot of germanium to actually kill a person; however it seems like even at the recommended dose it can create negative side-effects.
Again, I do not doubt that germanium is effective in certain applications; otherwise studies on it would have been abandoned. The fact that they are pursuing the studies indicates it has potential, but the fact that there are multiple previous studies showing toxicity indicate that caution and more study is warranted.
Therefore, I do not believe calling the FDA "full of lies" is appropriate, because plenty of studies support their caution. Thus I believe that the results of this 7-year study are ultimately going to be more conclusive than any of the previous studies.
Jack