Done many. Ovulation timing is key.. Peak progesterone is 21-25 for biggest litter. Make sure you give antibiotics and pain killer for a few days after. Usually doc will prescribe tramadol. Possible side effect constipation so feed some cottage cheese or yogurt. It's as easy as cake. Pups will be born 62 days from ovulation.. Not breeding date, which is usually day 59-60 from breeding